Jci ketohexokinase c blockade ameliorates fructoseinduced. Urtica dioica on fructose induced insulin resistance rats. Our aim in this study was to address whether diet induced insulin resistance plays any roles in the development of aortic and coronary atherosclerosis in hyperlipidemic rabbits. Substantial evidence suggests that increased dietary consumption of fructose induces insulin resistance in animals and humans 11. We fed watanabe heritable hyperlipidemic whhl rabbits with a. How safe is fructose for persons with or without diabetes. Don apocynaceae leaf powder alleviates high fructose diet induced insulin resistance and oxidative stress in rats. Grape polyphenols prevent fructoseinduced oxidative stress. Fructoseinduced insulin resistant states are commonly. Because insulin resistance and reduced insulin binding have been reported in hypertriacylglycerolemic persons, this may be one mechanism by which fructose diets promote insulin resistance. Antidiabetic effect of hydroalcholic urtica dioica leaf.
This result coincides with previous evidence showing that downregulation of insulin receptor in animals with insulin resistance induces nociceptive hypersensitivity romanovsky et al. Reaven summary to determine if hypertension could be produced in normal rats by feeding them a fructoseenriched diet, spraguedawley rats were fed either normal chow or a diet containing 66% fructose as a percentage of total. Plasma levels of glucose, insulin, total cholesterol, triglyceride, free fatty acids, and methylglyoxal were highly increased in fructoseinduced insulin resistant rats and treatment with metformin significantly improved this metabolic profile. The protective effect and underlying mechanism of metformin.
Therefore, we studied the effect of high fructose diet and fish oil on dnl and. In contrast, fish oil supplementation decreases triglycerides and may improve insulin resistance. Fructose, insulin resistance, and metabolic dyslipidemia. Islet adaptive changes to fructoseinduced insulin resistance. Unlike glucose, fructose induced metabolic syndrome is attributed mainly to the effect of fructose on insulin receptor phosphorylation while glucose induced metabolic syndrome is attributed to the. We and others have demonstrated that fructose is a major precursor of mg 6, 15. Improvement of liquid fructoseinduced adipose tissue. The consumption of large amounts of dietary fructose also can rapidly induce insulin resistance, postprandial hypertriglyceridemia, and blood pressure in humans more than starch or glucose does in controls 3, 5, 6. We investigated whether fructose induced leptin resistance in mice could be used to study the metabolic consequences of fructose consumption in humans, particularly in children and adolescents. Insulin resistance ir is recognized as a contributory factor for a variety of liver diseases. Paeoniflorin ameliorates fructoseinduced insulin resistance.
Hfd and sugarsweetened beverages are risk factors for developing obesity, insulin resistance, and fatty liver disease. Molecular and metabolic markers of fructose induced. Fructose, weight gain, and the insulin resistance syndrome. Effects of olive oil and guar on fructoseinduced insulin.
Two models of insulin resistance were used dexamethasone of pharmacy. Dietary fructose reduces circulating insulin and leptin. Role of the glucosamine pathway in fat induced insulin resistance meredith hawkins, nir barzilai, rong liu, meizhu hu, wei chen, and luciano rossetti division of endocrinology and diabetes research and training center, albert einstein college of medicine, new york 10461. Dietary fructose activates insulin signaling and inflammation. This pdf is available for free download from a site hosted by medknow publications. The aim of the present study was to examine the effects of streptozotocin, fructose and sucrose induced insulin resistance on plasma and urinary. An increase in the consumption of highsugar diets, especially of fructose, correlates positively with the development of hyperinsulinaemia, insulin resistance, hypertension and hypertriacylglycerolaemia 1. Effects of streptozotocin, fructose and sucroseinduced. The addition of clonidine to the drinking water inhibited fructose induced hypertension, but not the increase in plasma insulin or triglyceride concentration seen in fructose fed rats. The most important thing you can do as a person with diabetes is understand the following. Dec 23, 2006 after fructose induced insulin resistance had been established, 4week treatment with the anthocyaninrich extract 5 gkg of high fructose diet or pioglitazone 270 mgkg of high fructose diet ameliorated the glucose intolerance and hyperlipidemia, but the extract failed to reverse the fructose induced hyperinsulinemia as pioglitazone did. Fructose, insulin resistance, and metabolic dyslipidemia ncbi.
Increasing consumption of sugars is one of the contributing factors to the obesity epidemic. Highfructose diets have been implicated in obesity via impairment of leptin signaling in humans and rodents. At the heart of all forms of diabetes is insulin resistance. Plasma glucose a and insulin b concentrations at the baseline fasted and homair index c in watercontrol and fructosepairfed rats. Several groups in recent times have related the pathogenesis of renal haemodynamic changes in diabetes and most of the experimental diabetic conditions studied so far were carried out using streptozotocin injection only.
But at supraphysiologic concentrations, fructose is. Lack of aldolase b is associated with atp depletion and overactivation of hepatic khk induced by fructose. Orlicky, 1 christina cicerchi, 1 cholsoon jang, 2 nanxing li, 1 tamara milagres, 1 masanari kuwabara, 1 michael f. High intake of dietary fructose has been shown to exert a number of adverse metabolic effects in humans and experimental animals. Insulin resistance is a growing and significant health problem strongly associated with obesity, dyslipidaemia and type 2 diabetes mellitus. Fructose, weight gain, and the insulin resistance syndrome the. Pdf the metabolic syndrome is an important public health concern that predisposes individuals to.
Grape seed extract supplementation prevents highfructose. Fructoseinduced insulin resistance as a model of neuropathic. Metabolic effects of troglitazone on fructoseinduced insulin. We investigated whether fructoseinduced leptin resistance in mice could be used to study the metabolic consequences of fructose consumption in humans, particularly in children and adolescents. Molecular and metabolic markers of fructose induced hepatic insulin resistance in developing and adult rats are distinct and aegle marmelos is an. The reduction of endothelial nitric oxide no bioavailability by uric acid may be a mechanism for insulin resistance and hypertension. Fructose consumption induces insulin resistance, impaired glucose tolerance, hyperinsulinemia.
The fructosecontrol rats had free access to 10% fructose in their drinking water, while the consumption of fructose in the ginger20 or 50 mgkg treated by gavage daily rats was adjusted to that of the fructosecontrol rats. Thus, the metabolic changes associated with fructose induced hypertension are unlikely to be secondary to an increase in sympathetic activity. Nov 10, 2010 increasing consumption of sugars is one of the contributing factors to the obesity epidemic. Fructoseinduced insulin resistance may be secondary to alterations of lipid metabolism. Reversibility of fructoseinduced insulin resistance. The control rat received vehicle, the fructose and extract groups received fructose 10% for eight weeks. Results in the pcb group, fructose induced 1 a 20% decrease in hepatic insulin sensitivity index p fructose, but the magnitudes of the changes were larger with fructose. Both cane sugar and high fructose corn syrup contain glucose and fructose. Results in the pcb group, fructose induced 1 a 20% decrease in hepatic insulin sensitivity index p fructose induced insulin resistance animals and aqueous shallot extract is a stronger hypoglycemic agent than the garlic extract. The use of highfructose corn syrup and other sweeteners was 2,100 percent higher in 1997 than in 1909 and was associated with a higher rate of diabetes. Prevention of insulin resistance in rats by sh01d table 1 effect of sh01d administration 20 days on biochemical parameters in fructoseinduced insulin resistance in rats. Prevention of dexamethasoneand fructoseinduced insulin. Insulin resistance induced by highfructose diet potentiates. The results showed that paeoniflorin significantly decreased serum insulin and glucagon levels, improved.
Mean glucose levels a were slightly but significantly higher in fructosefed vs. Adult male wistar rats of body weight around 200 g were divided. This pdf is available for free download from a site hosted. Male spraguedawley rats were fed 20% fructose drink for eight weeks. The present study investigates the susceptibility of liver to the toxic actions of carbon tetrachloride ccl 4 in a rat model of ir, induced by feeding a high fructose. Effect of anthocyaninrich extract from black rice oryza. Effect of fructose overfeeding and fish oil administration. The control diet contained 46% carbohydrate, which is mainly composed of starch, whereas the fructose diet contained 60% fructose as the carbohydrate. Ketohexokinase c blockade ameliorates fructoseinduced. Our aim in this study was to address whether dietinduced insulin resistance plays any roles in the development of aortic and coronary atherosclerosis in hyperlipidemic rabbits. Fructose, in contrast to glucose, is known to potently stimulate lipogenesis, but the mechanisms responsible are not yet fully known. Ketohexokinase c blockade ameliorates fructoseinduced metabolic dysfunction in fructosesensitive mice.
It is thus correlated with the skyrocketing diabetes epidemic. The aim of the present study was to investigate whether catharanthus roseus l. Urtica dioica on fructoseinduced insulin resistance rats. Individuals with insulin resistance and resulting impaired glucose tolerance along with type 2 diabetes showed an increased prevalence of atherosclerosis. Moreover, it is a potential risk factor for fatty liver disease. Research was also done to clarify the difference between fructose and glucose in insulin resistance. Male c57bl6 mice were weaned to a randomly assigned diet. The current study interrogated these two proposed mechanisms in a mouse model of hepatic insulin resistance induced by a high fructose. Fructoseinduced insulin resistance downregulated insulin receptor. Fructose but not glucosesupplemented rats displayed an abnormal. Research paper prevention of dexamethasone and fructoseinduced insulin prevention of dexamethasone and fructoseinduced insulin resistance in rats by sh01d, a herbal preparation resistance in rats by sh01d, a herbal preparation. Mean glucose levels a were slightly but significantly higher in fructose fed vs.
Administration of benfluorex, a hypolipidemic agent, reversed the insulin resistance induced by fructose feeding in rats. Although there are no human studies that have assessed the effect of insulin sensitizing agents on fructose induced lipogenesis, a recent study suggests that pioglita. Nefa induced by fructose at the expense of their oxidation. Furthermore, existing hyperlipidemia andor insulin resistance may predispose individuals to greater postprandial hypertriglyceridemia after consuming fructose. Effect of fructose overfeeding and fish oil administration on. After fructoseinduced insulin resistance had been established, 4week treatment with the anthocyaninrich extract 5 gkg of highfructose diet or pioglitazone 270 mgkg of highfructose diet ameliorated the glucose intolerance and hyperlipidemia, but the extract failed to reverse the fructoseinduced hyperinsulinemia as pioglitazone did.
Reaven summary to determine if hypertension could be produced in normal rats by feeding them a fructose enriched diet, spraguedawley rats were fed either normal chow or a diet containing 66% fructose as a percentage of total. In the current study, we show that fructose induced metabolic syndrome is partially prevented by lowering serum uric acid in the rat. Forty male wistar rats were randomly divided into five groups including control, fructose, extract 50, extract 100 and extract 200. Fructoseinduced insulin resistance has been well established and characterized in rats 12, 14.
Role of the glucosamine pathway in fatinduced insulin resistance. In the fructosefed rats, the insulin resistance was reversed within 15 days after 2 months of exposure to fructoseenriched drinking water and within 30 days after 4 months exposure to the same drinking water cancelas et al. The effects of high fructose diet on adipose tissue insulin signaling and inflammatory process have been poorly documented. Fructoseinduced insulin resistance and hypertension in rats ishun hwang, helen ho, brian b. Don apocynaceae leaf powder alleviates highfructose dietinduced insulin resistance and oxidative stress in rats. The insulin sensitivity, serum lipid profiles, and hepatic. Pdf fructose, weight gain, and the insulin resistance syndrome.
A causal role for uric acid in fructoseinduced metabolic. Fructose, but not glucose, impairs insulin signaling in. Biochemical, histological, and molecular changes were investigated. The effects of highfructose diet on adipose tissue insulin signaling and inflammatory process have been poorly documented. We fed watanabe heritable hyperlipidemic whhl rabbits. Diabetes is caused by a fat metabolism disorder, which results in a glucose metabolism disorder.
Grape polyphenols prevent fructoseinduced oxidative. Cell metabolism 4 march 2009, volume 9, issue 3, pages 252264the role of peroxisome proliferatoractivated receptor gamma coactivator1 beta in the pathogenesis of fructoseinduced insulin resistance authors. Male spraguedawley rats 150200 g were housed in standard conditions and fed a control n 7 or 60% fructose diet harlan, madison, wi, n 14 for 10 wk. The incidence of type 2 diabetes and insulin resistance is increasing worldwide, a trend that is largely attributable to lifestyle choices. Fructose induced insulin resistance may be secondary to alterations of lipid metabolism. Fructose, but not glucose, impairs insulin signaling in the three. Metabolic effects of troglitazone on fructoseinduced insulin resistance in the rat. Results in the pcb group, fructose induced 1 a 20% decrease in hepatic insulin sensitivity index p may 12, 2015 insulin resistance, hyperglycemia, dyslipidemia and oxidative rout were induced in rats using high. The present study aimed to evaluate the effects of paeoniflorin on insulin resistance and hepatic steatosis induced by fructose.
Both cane sugar and highfructose corn syrup contain glucose and fructose. Prevention and reversal of dietinduced leptin resistance. Improvement of liquid fructoseinduced adipose tissue insulin. Fructoseinduced insulin resistance and hypertension in rats. Molecular and metabolic markers of fructose induced hepatic. Insulin resistance is a metabolic disorder that prevails worldwide and plays a role in pathophysiology of most common human diseases including type 2 diabetes mellitus, hypertension, obesity, dyslipidemia and coronary heart disease. Therefore, we studied the effect of highfructose diet and fish oil. In this study, we examined the influences of longterm fructose intake and resveratrol supplementation on the expression of genes involved in insulin signaling and the levels of inflammatory cytokines and sex hormones in the white adipose tissues of male and female rats. Ketohexokinase c blockade ameliorates fructose induced metabolic dysfunction in fructose sensitive mice miguel a. The insulin sensitivity, serum lipid profiles, and hepatic lipids contents were measured. Highfructose and highfat dietinduced insulin resistance. Three months of highfructose feeding fails to induce.
373 1095 349 952 564 1239 72 408 1323 1100 484 809 299 490 612 29 1344 657 1467 793 1382 885 571 1535 597 1157 116 16 767 519 133 266 900 531 1212