If an internal link led you here, you may wish to change the link to point directly to the intended article. Keshan disease and selenium status of populations in china. The following links will open a pdf file in a new browser window. Later on, kd was discovered in other areas of northeast and also southwest china, including sichuan and yunnan prov inces.
Three specific diseases have been associated with selenium deficiency. Keshan disease kd is a lifethreatening condition that affects the heart muscle. Keshan disease herbal treatment, prevention, symptoms. Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of. Care for patients with chronic diseases should be an integral part of the activities of health services, alongside care for patients with acute and infectious diseases. Selenium south tees hospitals nhs foundation trust. A collection of disease information resources and questions answered by our genetic and rare diseases information specialists for keshan disease. Yang institute of health, chinese academy of medical sciences, beijing, peoples republic of china keshan disease is an endemic cardiomyopathy which was first observed in keshan county, heilonjiang province, northeast china. Sentinel surveillance of keshan disease kd is limited by unable to give the prevalence rates and their estimates. Kashinbeck disease expanding the spectrum of iodine. Selenium deficiency also contributes to kashinbeck disease. It was first observed in keshan province in china, and it has since been found in other areas where the selenium level in the soil is low.
Pdf995 makes it easy and affordable to create professionalquality documents in the popular pdf file format. Introduction inflammatory bowel disease encompasses two idiopathic, chronic, inflammatory diseases. Read is selenium deficiency really the cause of keshan disease. Keshan disease, which results in an enlarged heart and poor heart function, occurs in selenium deficient children. In internet explorer, rightclick on the link and select save target as. A fatal heart disease first reported in keshan county of the greater metropolitan qiqihar of the heilongjiang province, mainland china, which affects children and young women. The treatment of chronic diseases demands a longterm and systematic approach. Causes of chronic kidney disease spanish niddk this document requires a coversheet. The role of selenium in keshan disease springerlink. Selenium is an essential mineral required by the body. Ashrae position document airborne infectious diseases. Investigation of a muscle disease in animals and a cluster of cases of cardiomyopathy in a region of china. In netscape, rightclick on the link and select save link as.
For language access assistance, contact the ncats public information officer. As one of several types of nutritional diseases, keshan disease is unique in. Deficiency can cause a rare heart disorder known as keshan disease. Keshan disease is a disease of heart muscle congestive cardiomyopathy which is potentially fatal. Adoption nutritionselenium deficiency keshan disease. Chen et al, institute of health, beijing, the peoples. Viral or bacterial infection some experts believe that coxsackievirus b3 may be involved in the cause of keshan s disease at least partly, but as they still have not identified if this is definitely the case, so it would be difficult to prevent keshan s disease from this cause. The prerequisite for success in this fight is the participation of all health care professionals. Keshan disease heart disease probably caused by a virus or toxin seen in china predisposed people to the disease toxicity losses and brittleness of hair and nails garlic breath odor nervous system abnormalitiesfood sources seafood, meat, grains, vegetables. Keshan disease, selenium deficiency, and the selenoproteome. Request pdf keshan disease, selenium deficiency, and the selenoproteome investigation of a muscle disease in animals and a cluster of cases of.
The main symptom of keshan disease is myocardial necrosis, leading to weakening of the heart. It was first observed in keshan province in china, and it has since been found in other areas where the selenium level in. This disambiguation page lists articles associated with the title keshan. Bone disease and kidney failure spanish american kidney fund this document requires a coversheet. Prevention of keshans disease health conditions vital. Kashinbeck disease results in atrophy, degeneration, and necrosis of cartilage tissue in the joints. Is selenium deficiency really the cause of keshan disease. Keshan disease selenium for treatment of keshan disease. It was first noted in the keshan province in heilongjiang, china. Genetic disease causes severe skin problems due to defect in zinc. Keshan disease, congestive cardiomyopathy caused by dietary deficiency in the mineral selenium. The following summarizes this document s revision, reaffirmation, or withdrawal dates. To research the causes of keshan disease, consider researching the causes of these these diseases that may be similar, or associated with keshan disease.
Gene microarray was used to screen differently expressed genes. Keshan disease uncountable a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of coxsackievirus. Kashinbeck disease definition of kashinbeck disease by. A condition caused by deficiency of the essential mineral selenium. Serum samples were collected from 112 kd patients and 112 normal controls. Its easytouse interface helps you to create pdf files by simply selecting the print command from any application, creating documents which can be viewed on any computer with a pdf viewer. Keshan disease a form of heart disease kashin beck disease. It is caused by a selenium deficiency and is characterized by pulmonary edema and heart failure. Component of the hormone thyroxine produced by the thyroid gland. As one of several types of nutritional diseases, keshan disease is unique in that it primarily affects young women and children. These symptoms were later found prevalent in a wide belt extending from northeast to southwest china, all due to seleniumdeficient soil. From 1984 to 1986, a national comprehensive scientific investigation on kd in chuxiong region of yunnan province in the southwest china was conducted. There is evidence that selenium deficiency may contribute to development of a form of heart disease, hypothyroidism, and a weakened immune system. However, molecular mechanism in the pathogenesis of kd remains poorly understood.
Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of coxsackievirus, named after keshan county of heilongjiang province, northeast china, where symptoms were first noted. Infections and infectious diseases are a great burden on many societies, including the countries in the who european region. Keshan disease is a potentially fatal form of cardiomyopathy disease of the heart muscle. Keshan disease kd is a kind of endemic cardiomyopathy which has a high mortality. Cms flexibilities to fight covid19 the trump administration is issuing an unprecedented array of temporary regulatory waivers and new rules to equip the american healthcare system with maximum flexibility to respond to.
Selenium is part of a nutritional antioxidant system that protects cell membranes and structural membranes from lipid peroxidation. It has also been suggested that keshans disease may. Keshan disease can be prevented, though not treated, by selenium supplementation, and widespread supplementation and probably also more varied diets have led to its neardisappearance in china. Nutritional factors that may be protective against cancer include. About this document on 1112 february 2020,who in collaboration with the global research collaboration for infectious disease preparedness and response glopidr an international network of funders to facilitate coordination and information sharing, organized a global forum on research and innovation for covid.
Keshan disease genetic and rare diseases information center. The dis ease was named keshan disease kd, because the out break was first occurred in the keshan county of heilong jiang province and its cause was unknown. Keshan disease a form of heart disease kashin beck school miami university. It was later found to be prevalent in a wide belt extending from southwest to northeast china. The icd code e59 is used to code keshan disease keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of coxsackievirus, named after keshan county of heilongjiang. To reduce that burden an integrated approach is required, combining health promotion, disease prevention and patient treatment. The heart disorder that is caused by selenium deficiency is keshan disease.
The principal pathological finding is multifocal necrosis of the myocardium that causes cardiac enlargement, congestive heart failure, cardiogenic shock, and death. If you have problems viewing pdf files, download the latest version of adobe reader. Keshan disease is a cardiomyopathy that occurs in certain regions of china. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. Which of the following fruits is likely to be the best source of vitamin a. Loss of heart tissue if keshans disease is not diagnosed and treated, then it can result in heart failure due to the selenium deficiency. Chronic respiratory diseases are a group of chronic diseases affecting the airways and the other. Crohns disease and ulcerative colitis are disorders of unknown cause, involving genetic and immunological influence on the gastrointestinal tracts ability to distinguish foreign. Keshan disease a form of heart disease kashin beck disease an arthritis. Keshan disease, an endemic cardiomyopathy occurring in lowselenium areas of china, was reported in 1979 to be.
Selenium is an antioxidant in the enzyme seleniumglutathione peroxidase. Keshan disease, an endemic cardiomyopathy occurring in lowselenium areas of china, was reported in 1979 to be responsive to supplementation with sodium selenite. Keshan disease and mitochondrial cardiomyopathy springerlink. The prevalence of keshan disease in china international journal. National laboratory of biomacromolecules, institute of biophysics, chinese academy of sciences, beijing 100101, china. Keshan disease definition of keshan disease by medical. Keshan disease kd is a potentially fatal form of cardiomyopathy disease of the heart muscle endemic in certain areas of china. The disease peaked in 19601970, claiming thousands of lives. Keshan disease is an inflammation of the heart muscle that causes a hearth illness known as cardiomyopathy. If you would like to save the pdf file to your computer, follow these steps.
805 614 532 285 320 158 1238 580 1515 470 16 1333 531 371 263 202 1141 196 690 278 695 867 871 500 395 340 199 1506 364 418 1377 811 133 1131 1171 1472 542 786 517 22